The constrains of physics, the confines of the manufacturing technology of the modern age, the limitations imposed by current material properties, requirements in terms of health and safety and cost: all of these are things that engineers must take into account when designing whatever it is they're working on. Luckily, M&E engineers are trained to recognise and solve these problems; but in order to recognise and solve them, engineers have to have a very particular set of skills, skills acquired over a long career, skills that make engineers a nightmare for anything these problems might throw at them.
The infographic below will highlight the characteristics that the M&E engineers need to succeed in the 4.0 era: